PCDHAC2 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	This antibody is suitable for immunohistochemistry on paraffin sections, immunofluorescence  and Western blotting. The suggested dilution is: Immunofluorescence: 1/10-1/50. Immunohistochemistry on paraffin sections:  1/10-1/50. Western blotting:  1/100-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the central region (between 623-652aa) of human PCDHAC2.
Specificity	This antibody detects human PCDHAC2.
Formulation	PBS with 0.09% (W/V) Sodium Azide. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a protein A column; followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protocadherin alpha subfamily C, 2
Database Link	Entrez Gene 56134 Human UniProt ID Q9Y5I4
Background	The PCDHAC2 gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Synonyms	Protocadherin alpha-C2, PCDH-alpha-C2
Note	Molecular Weight: 109450 Da
Reference Data
Protein Families	Transmembrane

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