REG3A (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	Western Blot: ~1/1000. Flow Cytometry: 1/10-/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of Human REG3A.
Specificity	This antibody recognizes Human REG3A (N-term).
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Peptide Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	regenerating family member 3 alpha
Database Link	Entrez Gene 5068 Human UniProt ID Q06141
Background	REG3A encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this protein is observed during pancreatic inflammation and liver carcinogenesis. Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. Tissue Location: Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
Synonyms	REG-3-alpha, Reg III-alpha, HIP, PAP, PAP1, Human proislet peptide, Pancreatitis-associated protein 1
Note	Molecular Weight: 19395 Da
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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