TIMP1 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blot: 1/1,000. Flow Cytometry: 1/10-1/50 Immunohistochemistry on paraffin sections: 1/50-1/100. Immunofluorescence: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 157-188 amino acids from the C-terminal region of human TIMP1
Specificity	This antibody detects TIMP1 (C-term).
Formulation	PBS State: Purified State: Liquid Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	TIMP metallopeptidase inhibitor 1
Database Link	Entrez Gene 7076 Human UniProt ID P01033
Background	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Synonyms	TIMP-1, TIMP, Tissue inhibitor of metalloproteinases, Metalloproteinase inhibitor 1, EPA, CLGI
Note	Molecular Weight: 23171 Da
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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