RNF103-CHMP3 Rabbit Polyclonal Antibody

CAT#: AP54843PU-N

RNF103-CHMP3 rabbit polyclonal antibody, Purified



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CNY 6,886.00


货期*
8周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommend Dilution ELISA.
Western Blot.
Immunohistochemistry.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from internal domain of Human Vps24 protein
Specificity Reacts with 25 kDa hVps24.
Formulation 0.1M Tris, 0.1M Glycine and 2% Sucrose
State: Purified
State: Lyophilized purified antibody
Preservative: None
Reconstitution Method Restore in distilled water.
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Condition

Prior to reconstitution store the antibody at -20°C.
Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name RNF103-CHMP3 readthrough
Background

The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP3, also known as Vps24, associates directly with CHMP2 and CHMP4 for the disassembly of ESCRT-III complex in an ATP-dependent manner. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. Overexpression of CHMP3 strongly inhibits HIV-1 release.
CHMP3 is expressed in brain, skeletal muscle, heart, lung, kidney and liver.

Synonyms CHMP3, NEDF, CGI-149
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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