Dyrk1a Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/1000. Immunohistochemistry: 1/50-1/200.
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	GST-rDyrk1A (Rat).
Specificity	This antibody reacts with 64 kDa of Rat Dyrk 1A. May cross react with other isoforms from Dyrk family and with Human protein.
Formulation	State: Serum State: Lyophilized serum Preservative: None
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	dual specificity tyrosine phosphorylation regulated kinase 1A
Database Link	Entrez Gene 25255 Rat UniProt ID Q63470
Background	Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dryk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Dyrk1A is a candidate gene that may be involved in Downs syndrome, and it has been found to be somewhat overexpressed in Downs syndrome.
Synonyms	DYRK, MNB, MNBH, Protein kinase minibrain homolog, HP86, Dual specificity YAK1-related kinase
Reference Data

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