HIST4H4 (Citrulline R3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/5000 - 1/10000. Immunohistochemistry: 1/100 - 1/1000. Western Blot: 1/100 - 1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from N-term region of Human Histone H4, containing Citrulline at position 3
Specificity	This antibody reacts with Histone H4 Citrulline at the position 3 (10 kDa). No cross reaction with free H4 or with other citrullinated proteins.
Formulation	State: Serum State: Lyophilized serum
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	histone cluster 4, H4
Database Link	Entrez Gene 121504 Human UniProt ID P62805
Background	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
Synonyms	HIST1H4, H4/A, H4FA
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.