PAR4 (PAWR) Rabbit Polyclonal Antibody
CAT#: AP55133PU-N
PAR4 (PAWR) rabbit polyclonal antibody, Purified
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CNY 6,886.00
货期*
8周
规格
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Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommend Dilution | ELISA. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide derived from internal domain of Human Par-4. |
Specificity | Reacts with Human 36 kDa Par-4 protein. |
Formulation | 0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified antibody Preservative: None |
Reconstitution Method | Restore in distilled water. |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Prior to reconstitution store the antibody at -20°C. |
Gene Name | pro-apoptotic WT1 regulator |
Database Link | |
Background | Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor. |
Synonyms | Par-4 |
Reference Data |
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