TMPRSS3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/500-1/2000. Immunohistochemistry: 1/100-1/500 (Immunopurified antibody is recommended).
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 15 residue synthetic peptide derived from specific domain of Human TMPRSS3 protein
Specificity	Reacts with Human 49 kDa TMPRSS3 protein.
Formulation	State: Serum State: Lyophilized serum Preservative: None
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	transmembrane protease, serine 3
Database Link	Entrez Gene 64699 Human UniProt ID P57727
Background	TMPRSS3 is a 437 amno acid membrane bound serine protease and a member of the S1 peptidase family. TMPRSS3 contains an amino-terminal signalanchor sequence and a glycosylated extracellular region containing the serine protease domain. Two novel missense mutations of TMPRSS3, W251C and P404L, alter the highly conserved amino acids of the serine protease domain. TMPRSS3 is expressed in many tissues, including fetal cochle,a a subset of pancreatic cancer and various other cancer tissues. TMPRSS3 is also overexpressed in cancer, suggesting that it may be important for processes in metastasis formation and tumor invasion.
Synonyms	Transmembrane protease serine 3, ECHOS1, TADG12, TADG-12
Reference Data

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