Sts1 (UBASH3B) Rabbit Polyclonal Antibody
CAT#: AP55364SU-N
Sts1 (UBASH3B) rabbit polyclonal antibody, Serum
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CNY 6,600.00
货期*
8周
规格
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Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommend Dilution | ELISA. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide derived from UBASH3B protein |
Specificity | This antibody reacts with 72 kDa protein. |
Formulation | State: Serum State: Lyophilized serum Preservative: None |
Conjugation | Unconjugated |
Storage Condition | Prior to reconstitution store the antibody at -20°C. |
Gene Name | ubiquitin associated and SH3 domain containing B |
Database Link | |
Background | Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens. |
Synonyms | KIAA1959, STS-1 |
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