USH2A (C-term) Rabbit Polyclonal Antibody

CAT#: AP55368PU-N

USH2A (C-term) rabbit polyclonal antibody, Purified



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CNY 6,886.00


货期*
8周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommend Dilution ELISA.
Western Blot: 1/200-1/2000.
Immunocytochemistry: 1/50-1/500.
Reactivity Human, Mus musculus
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from cytoplasmic (Cter domain) of mouse Ush2A
Specificity This antibody reacts with Human 570 kDa USH2A protein.
Cross reacts with Rat, Mouse and other species.
Formulation 0.1M Tris, 0.1M Glycine, 2% Sucrose
State: Purified
State: Lyophilized purified IgG fraction
Preservative: None
Reconstitution Method Restore in distilled water to a concentration of 1 mg/ml
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Gene Name usherin
Background The Usher 2A gene expresses an extra cellular matrix protein that resembles unconventional Myosin and do not appear to have any un-conventional functional correlations. It is expressed primarily in retina and cochlea and may be important in the development and homeostasis of the inner ear and retina. The human Usher Syndrome 2A (Ush2A) protein has several functional domains (Laminin type EGF like domain; Laminin-Type epidermal growth factor like domain and a fibronectin type 3 like domain). The protein has a single transmembrane domain that anchor the protein to the cell membrane, the rest of the protein stays outside the cell. Defects in the USH2A gene are the most common cause of deafness and blindness in adults and affect 3-6% children born with hearing impairments. The affected individuals have sensory-neural deficiencies at birth and subsequently develop progressive retinitis pigmentosa (RP). Three forms of Usher syndrome have been characterized, Usher Type 1, II and III which can be distinguish based on severity of hearing loss and vestibular involvement. Type I patents are profoundly deaf while type II (most common form of Usher syndrome) patients are mildly deaf but have normal in vestibular responses.
Synonyms Usher syndrome type IIa protein, Usher syndrome type-2A protein
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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