Cd68 Mouse Monoclonal Antibody [Clone ID: ED1]

Specifications

Product Data
Clone Name	ED1
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of Neat-1/10 diluted antibody to label 106 cells in 100 µl. Results maybe enhanced using membrane permeabilisation.
Reactivity	Bovine, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Rat spleen cells. Spleen cells from immunised BALB/c mice were fused with cells of the SP2/0-Ag14 mouse myeloma cell line.
Specificity	This antibody recognises CD68.
Formulation	PBS Label: PE State: Lyophilized purified IgG fraction. Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide Label: R. Phycoerythrin (RPE)
Reconstitution Method	Restore with 1 ml distilled water
Purification	Affinity Chromatography on Protein A
Conjugation	PE
Storage Condition	Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	Cd68 molecule
Database Link	Entrez Gene 287435 Rat UniProt ID Q4FZY1
Background	The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.
Synonyms	Gp110, Macrosialin, Macrophage marker
Reference Data

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