CD31 (PECAM1) Mouse Monoclonal Antibody [Clone ID: MEM-05]
CAT#: BM4047F
CD31 (PECAM1) mouse monoclonal antibody, clone MEM-05, FITC
Conjugation: Unconjugated Biotin
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CNY 3,810.00
Cited in 1 publication. |
Specifications
Product Data | |
Clone Name | MEM-05 |
Applications | FC |
Recommend Dilution | Flow Cytometry: Use 20 µl reagent/100 µl of whole blood or 106 cells in a suspension. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Leucocytes of patient suffering from LGL-type leukaemia |
Specificity | The antibody reacts with CD31, a 130-140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage. |
Formulation | Phosphate buffered saline (PBS) containing 15 mM Sodium Azide as preservative Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use. |
Conjugation | FITC |
Storage Condition | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Should it contain a precipitate we recommend microcentrifugation before use. |
Gene Name | platelet and endothelial cell adhesion molecule 1 |
Database Link | |
Background | CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in rebulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system. |
Synonyms | PECAM-1, EndoCAM, GPIIA' |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells
,Soupene E, Serikov V, Kuypers FA,
J. Lipid Res.
,PubMed ID 18268358
[PECAM1]
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