CD31 (PECAM1) Mouse Monoclonal Antibody [Clone ID: MEM-05]

CAT#: BM4047F

CD31 (PECAM1) mouse monoclonal antibody, clone MEM-05, FITC

Conjugation: Unconjugated Biotin FITC



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CNY 3,810.00


货期*
5周

规格
    • 100 Tests

Cited in 1 publication.

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Specifications

Product Data
Clone Name MEM-05
Applications FC
Recommend Dilution Flow Cytometry: Use 20 µl reagent/100 µl of whole blood or 106 cells in a suspension.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Leucocytes of patient suffering from LGL-type leukaemia
Specificity The antibody reacts with CD31, a 130-140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage.
Formulation Phosphate buffered saline (PBS) containing 15 mM Sodium Azide as preservative
Label: FITC
State: Liquid purified Ig fraction
Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use.
Conjugation FITC
Storage Condition Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light. Should it contain a precipitate we recommend microcentrifugation before use.
Gene Name platelet and endothelial cell adhesion molecule 1
Background CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in rebulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Synonyms PECAM-1, EndoCAM, GPIIA'
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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