CD31 (PECAM1) Mouse Monoclonal Antibody [Clone ID: MEM-05]

Specifications

Product Data
Clone Name	MEM-05
Applications	FC, WB
Recommend Dilution	Flow Cytometry: 1-10 µg/ml. Western Blot (non reducing conditions).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Leucocytes of patient suffering from LGL-type leukaemia
Specificity	The antibody reacts with CD31, a 130-140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage.
Formulation	Phosphate buffered saline (PBS) with 15 mM Sodium Azide, approx. pH 7.4 State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	platelet and endothelial cell adhesion molecule 1
Database Link	Entrez Gene 5175 Human UniProt ID P16284
Background	CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in rebulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Synonyms	PECAM-1, EndoCAM, GPIIA'
Reference Data

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