MHC Class II (I-A k,b,d,q,r) Rat Monoclonal Antibody [Clone ID: ER-TR3]

CAT#: BM4094B

MHC Class II (I-A k,b,d,q,r) rat monoclonal antibody, clone ER-TR3, Biotin

Conjugation: Unconjugated Biotin FITC



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CNY 9,300.00


货期*
5周

规格
    • 200 ug

Product images

Specifications

Product Data
Clone Name ER-TR3
Applications FC, IHC
Recommend Dilution Immunohistochemistry on Frozen Sections: 4 µg/ml (1/100).
Suggested Positive Control: Mouse spleen.
Does not react on routinely processed paraffin sections.
Has been reported to work in Flow Cytometry.
Reactivity Mouse
Host Rat
Clonality Monoclonal
Immunogen Murine thymic reticulum
Specificity This antibody detects cells expressing MHC class II antigens.
Monoclonal antibody ER-TR3 detects MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. it is a valuable tool for studying T-helper cell interaction with class II positive antigen presenting cells (dendritic cells, B-cells, macrophages). This antibody also offers new possibilities for studying the development of T-helper cells since it also stains stromal cells in the thymus.
Antigen Distribution
Isolated Cells: The antigen is found on dendritic cells, B-cells and macrophages.
Tissue sections: The antigen is found on B-cells, interdigitating cells and macrophages in peripheral lymphoid organs but is absent from T-cells. It is also expressed as a fine reticular pattern on stromal thymic cells of the cortex and as a confluent pattern on stromal thymic cells of the medulla.
Formulation Stock Solution contains PBS, pH 7.2 with 5 mg/ml BSA as a stabilizer with no preservative
Label: Biotin
State: Lyophilized purified Ig fraction
Reconstitution Method Restore with 0.5 ml distilled water.
Concentration 0.4 mg/ml
Purification Affinity Chromatography
Conjugation Biotin
Storage Condition Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Background MHC Class II antigens are heterodimers consisting of one alpha chain (31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR3, ER-TR2, ER-TR1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the Human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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