Lamin B1 (LMNB1) Mouse Monoclonal Antibody [Clone ID: 119D5-F1]

Specifications

Product Data
Clone Name	119D5-F1
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	ELISA.  Flow cytometry: 1/100-1/200.  Immunohistochemistry on Frozen Sections. Immunocytochemistry: 1/100-1/200 with Avidin-Biotinylated Horseradish peroxidase complex (ABC) as detection reagent. Western blot: 1/100-1/1000.
Reactivity	Bovine, Canine, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Rat liver lamins.  119D5-F1 is a Mouse monoclonal IgG1/k antibody derived by fusion of P3/X63.Ag8.653 mouse myeloma cells with spleen cells from a BALB/c mouse.
Specificity	The antibody Clone 119D5-F1 reacts with an epitope located C-terminal of residue 231 in Lamin B1.
Formulation	PBS containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	67 kDa (Predicted)
Gene Name	lamin B1
Database Link	Entrez Gene 4001 Human UniProt ID P20700
Background	Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane.Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2.  Lamins play a crucial role in the maintenance of nuclear structure, gene regulation, and signaling from cytoplasm to nucleus. Mutations in lamins have been associated with a number of pathologies; the so-called laminopathies.
Synonyms	Lamin-B1, LMNB1, LMNB-1, LMN2, LMNB, Nuclear Envelope Marker
Reference Data

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