Insulin (INS) (+Proinsulin) Mouse Monoclonal Antibody [Clone ID: D3E7 (5B6/6)]

Specifications

Product Data
Clone Name	D3E7 (5B6/6)
Applications	ELISA, IHC
Recommend Dilution	ELISA: This antibody is suitable for use as a Detection antibody with BM507 as the Capture antibody. Immunohistochemistry on Frozen Sections (Ref.1). Immunohistochemistry on Paraffin Sections: 1/100-1/300.
Reactivity	Bovine, Human, Mouse, Porcine, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human Insulin.
Specificity	This antibody recognizes both Insulin and Proinsulin, but does not react with free C-Peptide.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	insulin
Database Link	Entrez Gene 3630 Human UniProt ID P01308
Background	Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
Synonyms	INS
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways	Insulin signaling pathway, Maturity onset diabetes of the young, mTOR signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Regulation of autophagy, Type I diabetes mellitus, Type II diabetes mellitus

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