delta 2 Catenin (CTNND2) Mouse Monoclonal Antibody [Clone ID: J19]
CAT#: BM5099
delta 2 Catenin (CTNND2) mouse monoclonal antibody, clone J19, Supernatant
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CNY 4,280.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | J19 |
Applications | IHC, WB |
Recommend Dilution | Immunoblotting. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: Ready-to-use (only after microwave treatment). Positive Control: Murine Brain, Retina. |
Reactivity | Bovine, Human, Mouse, Rat, Zebrafish |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Synthetic peptide J6 (corresponding to aa 292-309), coupled to KLH |
Specificity | This Monoclonal antibody reacts specifically with Neurojungin (delta-catenin,a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Deltacatenin also binds to Presenilin-1, mutations of this protein are described to play a role in familial Alzheimer’s disease. No cross-reaction with other members of the Armadillo / Plakoglobin protein family. The antibody is positive with a 300 kD polypetide in Endothelia from blood vessels. |
Formulation | State: Supernatant State: Liquid Culture Supernatant with 0.09% Sodium Azide |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Gene Name | catenin delta 2 |
Database Link | |
Background | Delta-Catenin, is a member of the p120 catenin subfamily of catenins. Delta-Catenin/NPRAP was identified as a protein homologous to plakophilin 1 and as a protein interacting with the loop region of presenilin 1 (PS1), the gene most commonly mutated in Alzheimer's disease. Delta-Catenin/NPRAP is almost exclusively expressed in the central nervous system mainly during early brain development. Delta-Catenin/NPRAP has been shown to co-localize and interact with N-cadherin in the mouse brain and to undergo dynamic relocalization during brain development. |
Synonyms | CTNND2, NPRAP, Delta-catenin, Neurojungin, GT24 |
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