Desmin (DES) Mouse Monoclonal Antibody [Clone ID: D9]

Specifications

Product Data
Clone Name	D9
Applications	IHC, WB
Recommend Dilution	Immunoblotting. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Embedded Sections. Rrecommended Dilutions: 1/25-1/200 for immunohistochemistry with avidinbiotinylated horseradish peroxidase complex (ABC) as detection reagent) and 1/100–1/1000 for immunoblotting.
Reactivity	Chicken, Human, Mouse, Porcine, Rabbit, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Desmin isolated from Human leiomyoma.
Specificity	D9 reacts exclusively with Desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma.
Formulation	PBS State: Purified State: Liquid, purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	desmin
Database Link	Entrez Gene 1674 Human UniProt ID P17661
Background	Desmin (53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
Synonyms	DES
Reference Data

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