Lamin A/C Mouse Monoclonal Antibody [Clone ID: 131C3]

CAT#: BM6000P

Lamin A/C mouse monoclonal antibody, clone 131C3, Purified



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CNY 5,186.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Clone Name 131C3
Applications FC, IF, IHC, WB
Recommend Dilution Immunoblotting: 1/100-1/1000.
Flow Cytometry: 1/100-1/200.
Immunocytochemistry.
Immunohistochemistry on Frozen Sections: 1/100-1/200 with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent.
Reactivity Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep
Host Mouse
Clonality Monoclonal
Immunogen Purified Rat liver Lamins.
Specificity 131C3 reacts with an epitope located between residues 319-566 in Lamin A and C.
Immunoblotting of 131C3 recognizes Nuclear Lamins A and C in Human Fibroblasts.
Formulation PBS
State: Purified
State: Liquid purified IgG fraction
Preservative: 0.09% Sodium Azide
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name lamin A/C
Background Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
Synonyms LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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