Integrin alpha 3 (ITGA3) (3B Isoform specific) Mouse Monoclonal Antibody [Clone ID: 54B3]

Specifications

Product Data
Clone Name	54B3
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/100-1/1000. Immunocytochemistry. Immunohistochemistry on Frozen Sections: 1/25-1/200, with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide corresponding to a 32 amino acid stretch in the cytoplasmic domain of integrin α3B including an appending N-terminal cysteine coupled to keyhole limpet hemocyanin.
Specificity	54B3 recognizes specifically the cytoplasmic domain of integrin subunit a3B which is present in microvascular structures in brain and heart.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin subunit alpha 3
Database Link	Entrez Gene 3675 Human UniProt ID P26006
Background	Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated α and β subunits. More than 18 α and 8 β subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits α3 and α6, two cytoplasmic variants, A and B, have been identified.
Synonyms	Integrin alpha-3, ITGA-3, ITGAG3, MSK18, Galactoprotein B3, GAPB3, VLA-3 alpha chain, VLA3, FRP-2
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer

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