Cardiac Troponin I (TNNI3) (+ skeletal) Mouse Monoclonal Antibody [Clone ID: C5]

Specifications

Product Data
Clone Name	C5
Applications	ELISA, WB
Reactivity	Amphibian, Bovine, Chicken, Fish, Human, Mouse, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	Free human cardiac troponin I
Specificity	This antibody reacts equally with free cardiac Troponin I (cTnI) and cTnI forming complexes with other troponin components. Not affected by heparin, phosphorylation and oxidation. Recognizes an epitope located between amino acid residues 186 and 192 of cTnI. Cross-reacts with skeletal troponin I from human, rat and mouse.
Formulation	PBS, pH 7.4 containing 0,09% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	>90% pure (SDS-PAGE). Protein A chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	troponin I3, cardiac type
Database Link	Entrez Gene 7137 Human UniProt ID P19429
Background	Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.
Synonyms	TNNI3, TNNC1
Reference Data

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