Vasopressin (AVP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC
Recommend Dilution	ELISA: 1/2000-1/20,000. Immunofluorescence. Immunohistochemistry on Frozen Sections Immunohistochemistry on Paraffin Embedded Tissues. Recommended Positive Control: Hypothalamus and posterior lobe of the pituitary gland.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic Arginine Vasopressin conjugated to Bovine thyroglobulin
Specificity	This antibody is specific for Arginine Vasopressin, also known as antidiuretic hormone. The sequence of ARG-Vasopressin is 100% identical in a vast number of species such as Human, Mouse, Rat, Cat, Dog, Bovine, Sheep, Guinea Pig, so a broad species. crossreactivity is to be expected.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	arginine vasopressin
Database Link	Entrez Gene 551 Human UniProt ID P01185
Background	Vasopressin, also known as arginine vasopressin (AVP), or antidiuretic hormone (ADH), is a posterior pituitary hormone that is synthesised in the hypothalamus. Vasopressin is synthesised as a precursor protein that consists of arginine vasopressin and two associated proteins, neurophysin 2 and the glycopeptide copeptin. Vasopressin, together with its carrier protein neurophysin II, is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. Vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney and also causes vasoconstriction of the peripheral vessels. Vasopressin can also contract smooth muscle during parturition and lactation. It also plays a role in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in the vasopressin precursor cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI), which is characterised by persistant thirst, polydipsia and polyuria. Arginine vasopressin is a nine amino acid peptide secreted from the posterior pituitary in response to reductions in plasma volume and increases is plasma osmolarity. Its release triggers water reabsorption due to the insertion of aquaporins in the membranes of kidney tubules which transport solute-free water through tubular cells and back into the blood.
Synonyms	Arginine vasopressin, Antidiuretic Hormone, ARVP, AVP
Reference Data

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