Hepatitis B Surface Antigen / HBsAg (ad/ay) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	Avidin and streptavidin amplification systems for ELISA.
Reactivity	Hepatitis B Virus
Host	Rabbit
Clonality	Polyclonal
Immunogen	Hepatitis B surface antigen purified from human serum. Mixture of subtypes ad & ay
Specificity	Monospecific, reacts only with Hepatitis B surface antigen including the pre-S1 epitope. This antibody is non-reactive with normal human serum.
Formulation	10 mM PBS pH 7.2 with 0.09% sodium azide as preservative and no stabilizing proteins. Label: Biotin State: Liquid purified Ig fraction. Label: IgG fraction is covalently coupled with the N-Hydroxysuccinimide ester of under mild conditions to give a high degree of substitution
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Hepatitis B Virus (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.
Synonyms	HBV surface antigen, Hepatitis B Virus
Reference Data

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