Ceruloplasmin (CP) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections (1/20-1/200). ELISA (Has been used at dilutions as high as 1/400K in a simple ELISA with 0.1 µ/well coated).
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Native human Ceruloplasmin
Specificity	Recognizes Ceruloplasmin. This antibody shows minimal reactivity with related serum proteins.
Formulation	PBS, pH 7.2 contaioning 0.09% Sodium Azide as preservative. State: Ig Fraction State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate Fractionation
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ceruloplasmin (ferroxidase)
Database Link	Entrez Gene 1356 Human UniProt ID P00450
Background	Ceruloplasmin is a copper binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132kDa and occurs in plasma at a concentration of 150-500 mg/L. Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95% of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant and an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation and trauma and it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson’s disease, where levels are greatly reduced. Ceruloplasmin is extremely labile in plasma and rapidly degrades to 115kDa and 19kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of ceruloplasmin.
Synonyms	Ferroxidase, CP
Reference Data

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