ITM2B Chicken Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
Reactivity	Human
Host	Chicken
Clonality	Polyclonal
Immunogen	Peptide coupled to carrier protein.
Specificity	The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.
Formulation	PBS, pH 7.2, containing 0.09% sodium azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	1.0 mg /ml
Purification	Affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Do not freeze working dilutions Avoid repeated freezing and thawing.
Gene Name	integral membrane protein 2B
Database Link	Entrez Gene 9445 Human UniProt ID Q9Y287
Background	The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.
Synonyms	ITM2B, BRI, BRI2, Integral membrane protein 2B, Transmembrane protein BRI
Reference Data

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