Perilipin 3 (PLIN3) (N-term) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Frozen Sections: 1/100-1/200 for 1h at RT. Immunohistochemistry on Paraffin Sections: 1/100-1/200 for 1h at RT after microwave treatment (for Protocol cf. Straub et al. 2008). Western blot: 1/1000 (ECL).
Reactivity	Bovine, Human
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Synthetic peptide of TIP47 N-terminus (aa 1-16).
Specificity	The antibody is specific for TIP47 and does not cross-react with Adipophilin and Perilipin. Tested Reactivity on Cultured Cell Lines: e.g. PLC cells, pretreated with oleic acid.
Formulation	State: Serum State: Liquid Serum containing 0.09% sodium azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	perilipin 3
Database Link	Entrez Gene 10226 Human UniProt ID O60664
Background	TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex (cf. Diaz & Pfeffer; for alternative discussions of its role see e.g. Bulankina). The protein has been localized in milk fat globule membranes of human and bovine origin. It has been described also as a placental protein. Increased amounts are secreted into circulation of cervix carcinoma patients. After radical surgery TIP47 serum levels are decreased (cf. Than et al.). The protein probably is significant as an oncodevelopmental marker. TIP47 shows about 40% sequence homology to adipophilin.
Synonyms	M6PRBP1; PP17; TIP47
Reference Data

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