KRT75 Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting. Immunohistochemistry on Frozen Sections. Immunofluorescence Microscopy. Working Dilutions: 1/100-1/200 for Immunofluorescence Microscopy (Acetone fixation), 1/100 (4% Paraformaldehyde Fixation) and 1/2,000 for Western Blotting (ECL method). Incubation Time: 1h at RT.
Reactivity	Human, Mouse
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	KLH coupled Synthetic peptide of Human type II keratin K75 (formerly also designated K6hf)
Specificity	The antiserum stains specifically the companion layer (innermost layer of the outer root sheath) of the hair follicle. Although there is a considerable homology of keratin K75 (K6hf) to keratins K5 and K6, no cross-reactivity was observed, neither in Western blotting nor in Immunofluorescence microscopy.
Formulation	State: Serum State: Liquid stabilized serum Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	keratin 75
Database Link	Entrez Gene 9119 Human UniProt ID O95678
Background	KRT75 plays an essential role in hair and nail formation and is an essential component of keratin intermediate filaments in the companion layer of the hair follicle. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS).
Synonyms	KRT75, K6HF, KB18, Cytokeratin-75, CK75, Keratin-75, K75, Type II keratin-K6hf
Reference Data

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