alpha 2 Macroglobulin (A2M) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	Immunohistochemistry on frozen sections (1:20 - 1:200). ELISA.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Native Alpha-2 Macroglobulin
Specificity	This antibody detects alpha-2-Macroglobulin.
Formulation	PBS, pH 7.2, 0.09 % Sodium Azide State: Ig Fraction State: Liquid Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate fractionation
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C up to one week or (in aliquots) at -20 °C for longer. Centrifuge vial before opening. Avoid repeated freezing and thawing.
Gene Name	alpha-2-macroglobulin
Database Link	Entrez Gene 2 Human UniProt ID P01023
Background	Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.
Synonyms	Alpha-2-M, CPAMD5, Alpha 2 macroglobulin
Reference Data

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