Neurotrophin 3 (NTF3) Mouse Monoclonal Antibody [Clone ID: OTI5A2]

Specifications

Product Data
Clone Name	OTI5A2
Applications	IHC, WB
Recommend Dilution	WB: 1:5000, IHC 1:50, IF (1:100)
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein expressed in E.coli corresponding to amino acids 139-257 of human NT3
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	27.4 kDa
Gene Name	neurotrophin 3
Database Link	NP_001096124 Entrez Gene 18205 MouseEntrez Gene 81737 RatEntrez Gene 4908 Human UniProt ID P20783
Background	NT3 is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. It is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse
Synonyms	HDNF; NGF-2; NGF2; NT-3; NT3
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	MAPK signaling pathway, Neurotrophin signaling pathway

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