SSB Mouse Monoclonal Antibody [Clone ID: OTI3F11]

Specifications

Product Data
Clone Name	OTI3F11
Applications	IF, IHC, IP, WB
Recommend Dilution	WB 1:1000~2000, IHC 1:150, IF 1:100, IP 2ug/500ul
Reactivity	Human, Dog, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human SSB expression vector
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46.8 kDa
Gene Name	small RNA binding exonuclease protection factor La
Database Link	NP_003133 Entrez Gene 478787 DogEntrez Gene 710344 MonkeyEntrez Gene 6741 Human UniProt ID P05455
Background	La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).
Synonyms	La; La/SSB; LARP3
Reference Data
Protein Families	Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Systemic lupus erythematosus

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