MAN1 (LEMD3) Mouse Monoclonal Antibody [Clone ID: OTI3H2]

Specifications

Product Data
Clone Name	OTI3H2
Applications	IP, WB
Recommend Dilution	WB 1:500, IF 1:100, IP 2-4ug/mg
Reactivity	Human, Dog, Monkey, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human LEMD3 (NP_055134) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	100.0 kDa
Gene Name	LEM domain containing 3
Database Link	NP_055134 Entrez Gene 380664 MouseEntrez Gene 680066 RatEntrez Gene 608380 DogEntrez Gene 717597 MonkeyEntrez Gene 23592 Human UniProt ID Q9Y2U8
Background	This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
Synonyms	MAN1
Reference Data
Protein Families	Transmembrane

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