LMAN1 Mouse Monoclonal Antibody [Clone ID: OTI2B10]

Specifications

Product Data
Clone Name	OTI2B10
Applications	IF, WB
Recommend Dilution	WB 1:200~500, IF 1:100
Reactivity	Human, Monkey, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human LMAN1 (NP_005561) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	54.2 kDa
Gene Name	lectin, mannose binding 1
Database Link	NP_005561 Entrez Gene 70361 MouseEntrez Gene 116666 RatEntrez Gene 697449 MonkeyEntrez Gene 3998 Human UniProt ID P49257
Background	The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq]
Synonyms	ERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; MCFD1; MR60
Reference Data
Protein Families	Druggable Genome, Transmembrane

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