CD40 Mouse Monoclonal Antibody [Clone ID: OTI1F12]
CAT#: CF807575
Carrier-free (BSA/glycerol-free) CD40 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12)
Formulation: Standard
View other "OTI1F12" antibodies (4)
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CNY 3,999.00
Specifications
Product Data | |
Clone Name | OTI1F12 |
Applications | IHC, WB |
Recommend Dilution | WB 1:2000, IHC 1:150 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 21-166 of human CD40(NP_001241) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 28.4 kDa |
Gene Name | CD40 molecule |
Database Link | |
Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul |
Synonyms | Bp50; CDW40; p50; TNFRSF5 |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Cytokine-cytokine receptor interaction, Primary immunodeficiency, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Viral myocarditis |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA807575 | CD40 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
CNY 1,999.00 |
|
TA807575AM | CD40 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12), Biotinylated |
CNY 3,990.00 |
|
TA807575BM | CD40 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12), HRP conjugated |
CNY 3,990.00 |
|
TA807575S | CD40 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
CNY 800.00 |