SMC1 (SMC1A) Mouse Monoclonal Antibody [Clone ID: OTI5A1]

CAT#: CF809793

Carrier-free (BSA/glycerol-free) SMC1A mouse monoclonal antibody,clone OTI5A1

Formulation: Standard Carrier-Free



  View other "OTI5A1" antibodies (4)

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CNY 3,999.00


货期*
2周

规格
    • 100 ug

经常一起买 (2)
Biotinylation Labelling Kit formatted 4 x 0.05mg
    • 200 ug

CNY 3,170.00


HRP Conjugation kit for 0.2mg IgG
    • 200 ug

CNY 3,230.00

Specifications

Product Data
Clone Name OTI5A1
Applications IHC, WB
Recommend Dilution WB 1:500, IHC 1:500
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 889-1016 of human SMC1A (NP_006297) produced in E.coli.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name structural maintenance of chromosomes 1A
Background Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Synonyms CDLS2; DXS423E; SB1.8; SMC1; SMC1alpha; SMC1L1; SMCB
Reference Data
Protein Families Druggable Genome
Protein Pathways Cell cycle, Oocyte meiosis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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