UAP56 (DDX39B) Mouse Monoclonal Antibody [Clone ID: OTI2C12]
CAT#: CF812661
Carrier-free (BSA/glycerol-free) DDX39B mouse monoclonal antibody,clone OTI2C12
Formulation: Standard
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CNY 3,999.00
Cited in 1 publication. |
Specifications
Product Data | |
Clone Name | OTI2C12 |
Applications | WB |
Recommend Dilution | WB 1:500 |
Reactivity | Human, Dog, Monkey, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 319-428 of human DDX39B (NP_004631) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 48.8 kDa |
Gene Name | DExD-box helicase 39B |
Database Link | |
Background | Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. [UniProtKB/Swiss-Prot Function] |
Synonyms | BAT1; D6S81E; UAP56 |
Reference Data | |
Protein Pathways | Spliceosome |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
---|
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy
,null,
BMC Biology
,PubMed ID 32209106
[DDX39B]
|
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA812661 | DDX39B mouse monoclonal antibody,clone OTI2C12 |
CNY 1,999.00 |
|
TA812661AM | DDX39B mouse monoclonal antibody,clone OTI2C12, Biotinylated |
CNY 3,990.00 |
|
TA812661BM | DDX39B mouse monoclonal antibody,clone OTI2C12, HRP conjugated |
CNY 3,990.00 |
|
TA812661S | DDX39B mouse monoclonal antibody,clone OTI2C12 |
CNY 800.00 |