Ly75 Rat Monoclonal Antibody [Clone ID: NLDC-145]

Specifications

Product Data
Clone Name	NLDC-145
Applications	FC, IF, IHC
Recommend Dilution	Flow Cytometry, IHC, IF
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Mouse lymphoid tissue stroma.
Specificity	Mouse dendritic cells.
Formulation	Tris-NaCl pH 8 State: Purified
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	lymphocyte antigen 75
Database Link	Entrez Gene 17076 Mouse UniProt ID Q60767
Background	NLDC-145 has been described as reacting specifically with a group of nonlymphoid dendritic cells including Langerhans cells (LC), veiled cells (VC), and interdigitating cells (IDC). The antibody does not react with precursor cells in bone marrow and blood. Macrophages are not stained by the antibody, but a subpopulation of Ia+ peritoneal exudate cells is recognized. It stains DC in T lymphocyte areas, including spleen white pulp but not spleen marginal zone DC or LC. The Ag is also expressed on activated macrophages and thymic cortical epithelium. DEC-205 has some similarities with mannose receptors and acts as a receptor for Ag uptake. (Kraal G., et al, J.Exp.med. 1986, 163, 981 ; Steinman RM, et al, PNAS, 2002, 99, 351-358 ; Flores-Langarica et al, PNAS, 2005, 102, 19039-19044) ATCC ref: HB-290TM.
Synonyms	LY75, CLEC13B, DEC205, gp200-MR6
Reference Data

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