CD40 Mouse Monoclonal Antibody [Clone ID: MAB89]
CAT#: DDX0131A488-100
CD40 mouse monoclonal antibody, clone MAB89
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CNY 6,000.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | MAB89 |
Applications | FC, IF |
Recommend Dilution | FACS surface, ImmunoFluorescence |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | anti-μ activated tonsillar human B cells |
Specificity | human CD40 |
Formulation | 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol Label: Alexa Fluor 488 |
Concentration | lot specific |
Purification | QMA Hyper D ion exchange chromatography |
Conjugation | Alexa Fluor 488 |
Storage Condition | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
Gene Name | CD40 molecule |
Database Link | |
Background | CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin. (Vallé A. et al, 1989; Eur. J. Immunol., 19: 1463-1469; O’ Sullivan B. et al, 2003; Crit. Rev. Immunol., 23: 83-107) |
Synonyms | TNFRSF5, CDw40, Bp50 |
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