CD40 Mouse Monoclonal Antibody [Clone ID: MAB89]

CAT#: DDX0131A488-100

CD40 mouse monoclonal antibody, clone MAB89



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CNY 6,000.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name MAB89
Applications FC, IF
Recommend Dilution FACS surface, ImmunoFluorescence
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen anti-μ activated tonsillar human B cells
Specificity human CD40
Formulation 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol
Label: Alexa Fluor 488
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Alexa Fluor 488
Storage Condition -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name CD40 molecule
Background CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.
(Vallé A. et al, 1989; Eur. J. Immunol., 19: 1463-1469; O’ Sullivan B. et al, 2003; Crit. Rev. Immunol., 23: 83-107)
Synonyms TNFRSF5, CDw40, Bp50
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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