ICAM1 Mouse Monoclonal Antibody [Clone ID: 217E2.10]

Specifications

Product Data
Clone Name	217E2.10
Applications	FC, IF
Recommend Dilution	DDX0151P-50 / DDX0151P-100 Purified: Flow cytometry, IHC (cryosection, paraffin), IF. DDX0151A488-50 / DDX0151A488-100 Alexa-fluor® 488: Flow cytometry, IF ( On request). DDX0151A546-50 / DDX0151A546-100 Alexa- fluor® 546: Flow cytometry, IF ( On request). DDX0151A647-50 / DDX0151A647-100 Alexa- fluor® 647: Flow cytometry, IF ( On request).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	in vitro-derived DCs (GM-CSF+TNF )
Formulation	Purified: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol Label: Alexa Fluor 546
Concentration	lot specific
Conjugation	Alexa Fluor 546
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	intercellular adhesion molecule 1
Database Link	Entrez Gene 3383 Human UniProt ID P05362
Background	217E2 monoclonal antibody was obtained following mouse immunization with in vitro-derived human dendritic cells. The target antigen was found to be CD54/ICAM-1, a cell surface glycoprotein which is typically expressed on endothelial cells and immune cells. CD54/ICAM-1, member of the Ig superfamily, binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also a receptor for rhinovirus. CD54/ICAM-1 is a type of intracellular adhesion molecule, playing a role in transmigration of endothelial cells into tissues through binding to LFA-1. (Carlson M.et al, 1988, Nucleic Acids Res. 16 (9): 4188; Yang L. et al, 2005, Blood 106 (2): 584).
Synonyms	ICAM-1
Reference Data

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