LAMP3 Mouse Monoclonal Antibody [Clone ID: 104G4]
CAT#: DDX0190A647-100
LAMP3 mouse monoclonal antibody, clone 104G4
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CNY 6,000.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | 104G4 |
Applications | FC |
Recommend Dilution | Intracyto Flow cytometry |
Reactivity | Human, Sheep |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | human DC-LAMP alkaline phosphatase fusion protein |
Specificity | human DC-LAMP (epitope in intracytoplasmic domain). Species cross-reactivity: sheep. |
Formulation | PBS 50% glycerol Label: Alexa Fluor 647 |
Concentration | lot specific |
Conjugation | Alexa Fluor 647 |
Storage Condition | -20°C. KEEP CONTENTS STERILE: no preservative. Coupled antibodies: glycerol protects from freezing. |
Gene Name | lysosomal associated membrane protein 3 |
Database Link | |
Background | The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al, 1998 ; Immunity ; 9:325-336) |
Synonyms | DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker |
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