LAMP3 Mouse Monoclonal Antibody [Clone ID: 104G4]

Specifications

Product Data
Clone Name	104G4
Applications	FC, IF, IHC
Recommend Dilution	Intracyto Flow cytometry, IHC
Reactivity	Human, Sheep
Host	Mouse
Clonality	Monoclonal
Immunogen	human DC-LAMP alkaline phosphatase fusion protein
Specificity	human DC-LAMP (epitope in intracytoplasmic domain). Species cross-reactivity: Sheep
Formulation	Tris-NaCl pH 8 State: Purified
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	lysosomal associated membrane protein 3
Database Link	Entrez Gene 27074 Human UniProt ID Q9UQV4
Background	The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al, 1998 ; Immunity ; 9:325-336)
Synonyms	DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker
Reference Data

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