LAMP3 Rat Monoclonal Antibody [Clone ID: 1010E1.01]
CAT#: DDX0191P-100
LAMP3 rat monoclonal antibody, clone 1010E1.01
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CNY 4,988.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | 1010E1.01 |
Applications | IHC |
Recommend Dilution | IHC paraffin (formol, Bouin) in human |
Reactivity | Canine, Feline, Human, Mouse, Sheep |
Host | Rat |
Clonality | Monoclonal |
Immunogen | recombinant murine DC LAMP |
Specificity | murine DC-LAMP (epitope in intracytoplasmic domain). Species cross-reactivity: human, cat, dog, sheep, mouse. |
Formulation | Tris-NaCl pH 8 State: Purified |
Concentration | lot specific |
Purification | QMA Hyper D ion exchange chromatography |
Conjugation | Unconjugated |
Storage Condition | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. |
Gene Name | lysosomal associated membrane protein 3 |
Database Link | |
Background | The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, DC-LAMP is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336 ; Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619- 29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71) |
Synonyms | DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker |
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