LAMP3 Mouse Monoclonal Antibody [Clone ID: 109G3]

Specifications

Product Data
Clone Name	109G3
Applications	FC, IF
Recommend Dilution	DDX0193P-50 / DDX0193P-100 Purified: FACS intracellular, ImmunoHistoChemistry frozen sections. DDX0193A488-50 / DDX0193A488-100 Alexa-fluor®488: FACS intracellular, Immunofluorescence. DDX0193A546-50 / DDX0193A546-100 Alexa-fluor®546: Immunofluorescence. DDX0193A647-50 / DDX0193A647-100 Alexa-fluor®647: FACS intracellular. DDX0193B-50 / DDX0193B-100 Biotin (on request): FACS intracellular, ImmunoHistoChemistry frozen sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human DC-LAMP alkaline phosphatase fusion protein.
Specificity	Human DC-LAMP (epitope in intracytoplasmic domain).
Formulation	Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol Label: Alexa Fluor 488
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Alexa Fluor 488
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	lysosomal associated membrane protein 3
Database Link	Entrez Gene 27074 Human UniProt ID Q9UQV4
Background	The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in the mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336)
Synonyms	DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker
Reference Data

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