DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: 111H2.02]
CAT#: DDX0209A488-100
DC SIGN (CD209) mouse monoclonal antibody, clone 111H2.02
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CNY 6,281.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | 111H2.02 |
Applications | FC |
Recommend Dilution | DDX0209P-50 / DDX0209P-100 purified: Surface flow cytometry, IHC Formol- paraffin, Bouin paraffin, Histowax. DDX0209A488-50 / DDX0209A488-100 Alexa-Fluor®488: Surface Flow cytometry. DDX0209A546-50 / DDX0209A546-100 Alexa-Fluor®647: IF. DDX0209A647-50 / DDX0209A647-100 Alexa-Fluor®647: Surface Flow cytometry. DDX0209B-50 DDX0209B-100 Biotin (on request): Surface Flow cytometry, IHC. Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before use. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | HeLa cells stably transfected-with human DC-SIGN. |
Specificity | Human DC-SIGN. Species cross-reactivity: positive staining on NIH3T3-transfected LSIGN. |
Formulation | Purified: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol. Label: Alexa Fluor 488 |
Concentration | lot specific |
Conjugation | Alexa Fluor 488 |
Storage Condition | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
Gene Name | CD209 molecule |
Database Link | |
Background | DC-SIGN (“DC Specific, ICAM-3 Grabbing, Nonintegrin”)/CD209 and liver/lymph node-specific ICAM-3-grabbing nonintegrin (L-SIGN) (CD299/DC-SIGNR for DC-SIGN-related molecule; DC-SIGN2) are closely related genes that map to chromosome 19p13.3.Both genes encode a member of the C-type lectin family of type II transmembrane proteins. The two receptors are 77% identical at the amino acid level, have similar ligands. They are expressed in different tissues. Both receptors have been shown to interact with ICAM-3 DC-SIGN is a high affinity receptor for HIV gp120 (Soilleux EJ. 2003, Clinical Science 104, 437-; Dakappagari N., et al. 2006, The J Immunol, 176, 426; Geijtenbeeck T.B., et al. 2000, Cell, 100, 57 ; .Bashirova A. et al., 2001, J.Exp. Med., 193, 671). The clone 111H2.02 anti-DC-SIGN blocks HIVgp120-DC-SIGN interaction and reacts on formalin-fixed tissues (Canard B et al, Immunol Lett. 2011, 135(1-2):165-72). |
Synonyms | DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker |
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