Peptidase 1 / DERP1 Human Monoclonal Antibody [Clone ID: H.AK5.C]

CAT#: DDX0212P-100

Peptidase 1 / DERP1 human monoclonal antibody, clone H.AK5.C



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CNY 8,775.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Clone Name H.AK5.C
Applications ELISA, WB
Recommend Dilution ELISA, Western Blot, Biopanning. 
Usage recommendation:

*This monoclonal antibody may be used between 1-20 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Reactivity Human
Host Human
Clonality Monoclonal
Immunogen EBV cell clones derived from PBMC of allergic patients to DPT.
Specificity allergen of the house-dust mites Dermatophagoides pteronyssinus Derp 1
Formulation 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
State: Purified
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Unconjugated
Storage Condition -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Background House-dust mite allergy belongs to the most common allergies worldwide which affect more than 50% of all allergic patients. House dust mite allergens play an important role in inducing IgE-mediated sensitization and the development of bronchial hyperresponsiveness and asthma, perennial rhinitis, and atopic dermatitis. Allergic patients’s sera (IgE) recognize the house-dust mite Dermatophagoides Pteronyssinus Derp 1. The key event in these reactions is the cross-linking of IgE antibodies on effector cells by allergens, which induces a release of biologically active mediators like histamine and leukotrienes leading to different symptoms of allergy. Studies in vivo have shown that the cysteine peptidase activity of group 1 house dust mite allergens contributes to their allergenicity.
(Chapman MD, 1980; J. Immunol., 125: 587-592; Hales BJ, Thomas WR., 1997; Clin. Exp. Allergy, 27(8):868- 875; Doull IJ. et al, 1997; Allergy, 52,220; Custovic A, 1996; J. Allergy Clin. Immunol., 98: 64- 72; Szalai K. et al., 2008; Mol. Immunol. 45:5, 1308-17)
Synonyms Allergen Der p I
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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