Langerin (CD207) Mouse Monoclonal Antibody [Clone ID: 310F7.02/HD26]

Specifications

Product Data
Clone Name	310F7.02/HD26
Applications	FC, IF
Recommend Dilution	Intracellular Flow cytometry, IF
Reactivity	Human, Mouse, Porcine, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	mouse Langerin-transfected eukaryotic cells
Specificity	mouse Langerin (intracellular epitope)
Formulation	PBS 50% glycerol Label: Alexa Fluor 488
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Alexa Fluor 488
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	CD207 molecule
Database Link	Entrez Gene 50489 Human UniProt ID Q9UJ71
Background	Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 2002 J. Immunol, 168 : 782-792) (Douillard P et al, 2005 J Invest Dermatol, 125: 983–994)
Synonyms	CLEC4K, Dendritic Cell Marker
Reference Data

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