Langerin (CD207) Rat Monoclonal Antibody [Clone ID: 929F3.01]
CAT#: DDX0362A546-100
Langerin (CD207) rat monoclonal antibody, clone 929F3.01
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CNY 6,281.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | 929F3.01 |
Applications | FC, IF, IHC |
Recommend Dilution | IF, IHC, Flow cytometry. Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. |
Reactivity | Human, Mouse, Porcine, Rat |
Host | Rat |
Clonality | Monoclonal |
Immunogen | human Langerin-transfected eukaryotic cells |
Specificity | Human Langerin. Species cross-reactivity: Rat, Mouse, Swine. |
Formulation | 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol Label: Alexa Fluor 546 |
Concentration | lot specific |
Conjugation | Alexa Fluor 546 |
Storage Condition | Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
Gene Name | CD207 molecule |
Database Link | |
Background | Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck’s granule. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin expression has not been reported outside the DC system. Human Langerin is involved in the processing of mycobacterial glycolipids leading to antigen presentation to CD1a-restricted T cells. Human Langerin binds the gp120 of HIV. (Valladeau J et al, 2002 J. Immunol, 168 : 782-792; Douillard P et al, 2005 J Invest Dermatol, 125: 983–994; Chorro L. et al, J Exp.Med., 2010, 206 (13), 3089-3100). |
Synonyms | CLEC4K, Dendritic Cell Marker |
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