Langerin (CD207) Mouse Monoclonal Antibody [Clone ID: 306G9.01/HD24]

Specifications

Product Data
Clone Name	306G9.01/HD24
Applications	IF
Recommend Dilution	Flow cytometry, IF, IHC. Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before using.
Reactivity	Human, Mouse, Porcine, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Mouse langerin–transfected COP5 cells.
Specificity	Mouse and Human Langerin (intracellular epitope). Species cross- reactivity: Human, Rat, Swine.
Formulation	Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol. Label: Alexa Fluor 546
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Alexa Fluor 546
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	CD207 molecule
Database Link	Entrez Gene 50489 Human UniProt ID Q9UJ71
Background	Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. In mouse, clone 306G9 stains lymph node dendritic cells (Henri et al, 2001, J. Immunol, 167: 741-748) (Valladeau J. et al, 2002 J Immunol, 168: 782).
Synonyms	CLEC4K, Dendritic Cell Marker
Reference Data

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