SEMA6A Mouse Monoclonal Antibody [Clone ID: 118E7]
CAT#: DDX0463P-100
SEMA6A mouse monoclonal antibody, clone 118E7
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CNY 4,988.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | 118E7 |
Applications | FC |
Recommend Dilution | DDX0463P-50 / DDX0463P-100 Purified: Surface Flow Cytometry. DDX0463A488-50 / DDX0463A488-100 Alexa-fluor®488: Surface Flow Cytometry. DDX0463A546-50 / DDX0463A546-100 Alexa-fluor®546: IF. DDX0463A647-50 / DDX0463A647-100 Alexa- fluor®647: (on request) IHC, Flow cytometry. Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before using. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | human recombinant SEMA-6A |
Specificity | Human SEMA-6A (epitope in extracellular domain). |
Formulation | Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol. State: Purified |
Concentration | lot specific |
Purification | QMA Hyper D ion exchange chromatography |
Conjugation | Unconjugated |
Storage Condition | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
Gene Name | semaphorin 6A |
Database Link | |
Background | Semaphorins represent a large family composed of 19 secreted, GPI-linked or transmembrane members divided into 5 classes (3 to 7) and characterized by the presence of a 500 amino acid Sema domain in the Nterminus. Initially described for their role in axon guidance and apoptosis during neuronal development, some semaphorins like the class 4 regulate immune functions and are involved in organogenesis and angiogenesis. The transmembrane class 6 semaphorins include 4 members (SEMA-6A to 6D). SEMA-6A features an intracellular binding site for regulatory Evl protein. In the immune system, SEMA6A protein is restricted in vitro and in vivo to an activation status of Langerhans cells. (Gautier G et al., 2006 Am J Pathol., 168: 453-65). |
Synonyms | Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, SEMAQ, KIAA1368 |
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