IL7R alpha (IL7R) Mouse Monoclonal Antibody [Clone ID: R34-34]
CAT#: DDX0700A546-100
IL7R alpha (IL7R) mouse monoclonal antibody, clone R34-34
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CNY 6,000.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | R34-34 |
Applications | IF |
Recommend Dilution | DDX0700P-50 / DDX0700P-100 Purified: FACS surface, Neutralization (IL7- binding inhibition), Immunoprecipitation. DDX0700A488-50 / DDX0700A488-100 Alexa-fluor®488: Surface Flow cytometry. DDX0700A546-50 / DDX0700A546-100 Alexa-fluor®546: IF. DDX0700A647-50 / DDX0700A647-100 Alexa-fluor®647: Surface Flow cytometry. Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before using. |
Reactivity | Canine, Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human leukemic pre-B cells. |
Specificity | Human IL7-Rα. |
Formulation | Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200μl / 50 μg in 100 μl Tris PBS 50% glycerol. Label: Alexa Fluor 546 |
Concentration | lot specific |
Purification | QMA Hyper D ion exchange chromatography |
Conjugation | Alexa Fluor 546 |
Storage Condition | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
Gene Name | interleukin 7 receptor |
Database Link | |
Background | The IL7-R consists of 2 chains, IL-7Rα known as CD127 and common cytokine receptor γ chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7Rα expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 ; Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54). |
Synonyms | Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL7 receptor alpha |
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