IL7R alpha (IL7R) Mouse Monoclonal Antibody [Clone ID: R34-34]

CAT#: DDX0700A546-100

IL7R alpha (IL7R) mouse monoclonal antibody, clone R34-34



Need it in bulk or conjugated?
Get a free quote

CNY 6,000.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name R34-34
Applications IF
Recommend Dilution DDX0700P-50 / DDX0700P-100 Purified: FACS surface, Neutralization (IL7- binding inhibition), Immunoprecipitation.
DDX0700A488-50 / DDX0700A488-100 Alexa-fluor®488: Surface Flow cytometry.
DDX0700A546-50 / DDX0700A546-100 Alexa-fluor®546: 
IF.
DDX0700A647-50 / DDX0700A647-100 Alexa-fluor®647:
 Surface Flow cytometry.

Usage recommendation:

*This monoclonal antibody may be used between 5-20 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before using.
Reactivity Canine, Human
Host Mouse
Clonality Monoclonal
Immunogen Human leukemic pre-B cells.
Specificity Human IL7-Rα.
Formulation Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl Tris PBS 50% glycerol.
Label: Alexa Fluor 546
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Alexa Fluor 546
Storage Condition -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name interleukin 7 receptor
Background The IL7-R consists of 2 chains, IL-7Rα known as CD127 and common cytokine receptor γ chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7Rα expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 ; Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54).
Synonyms Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL7 receptor alpha
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...