IL8 (CXCL8) Mouse Monoclonal Antibody [Clone ID: I8-60]

Specifications

Product Data
Clone Name	I8-60
Applications	ELISA
Recommend Dilution	ELISA: This HRP conjugated antibody can be used as a tracer antibody in sandwich ELISA applications for human IL-8 detection in combination with a monoclonal capture antibody (Cat.-No DM1022).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant human IL-8 (monocyte-derive, 72-amino acid form)
Specificity	This antibody recognizes both, natural and recombinant IL-8. No cross-reactivity with human monocyte chemotactic activating factor (MCP-1) or RANTES (Regulated on Activation, Normal T-cell Expressed, and Secreted)
Formulation	0.01M PBS, pH 7.0 ± 0.1 in 50% Glycerol and 0.01% thimerosal as a bacteriostat Label: HRP State: Liquid purified IgG fraction Label: Horseradish Peroxidase
Purification	Affinity Chromatography on Protein G
Conjugation	HRP
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	C-X-C motif chemokine ligand 8
Database Link	Entrez Gene 3576 Human UniProt ID P10145
Background	IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood. This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes. Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
Synonyms	CXCL8, Protein 3-10C, Emoctakin, GCP1, MDNCF, MONAP, NAP1
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Bladder cancer, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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